Select CGI Publications

CGI’s founder, Dr. Chaganti, is a leading expert on the genetics and biology of lymphomas and germ cell tumors.  His laboratory at Memorial Sloan-Kettering Cancer Center has produced more than 300 papers in the identification of genetic alterations associated with these cancers as highlighted: 

Pathway activation in large B-cell non-Hodgkin lymphoma cell lines by doxorubicin reveals prognostic markers of in vivo response.

Houldsworth J, Petlakh M, Olshen AB, Chaganti RS.

Leuk Lymphoma. 2008. 49(11):2170-80.

Molecular cytogenetic analysis of follicular lymphoma (FL) provides detailed characterization of chromosomal instability associated with the t(14;18)(q32;q21) positive and negative subsets and histologic progression.

Nanjangud G, Rao PH, Teruya-Feldstein J, Donnelly G, Qin J, Mehra S, Jhanwar SC, Zelenetz AD, Chaganti RS.

Cytogenet Genome Res. 2007. 118(2-4):337-44.

Array comparative genomic hybridization reveals genomic copy number changes associated with outcome in diffuse large B-cell lymphomas.

Chen W, Houldsworth J, Olshen AB, Nanjangud G, Chaganti S, Venkatraman ES, Halaas J, Teruya-Feldstein J, Zelenetz AD, Chaganti RS.

Blood. 2006. 107(6):2477-85.

Genomic amplification of the human telomerase gene (TERC) in pap smears predicts the development of cervical cancer.

Heselmeyer-Haddad K, Sommerfeld K, White NM, Chaudhri N, Morrison LE, Palanisamy N, Wang ZY, Auer G, Steinberg W, Ried T.

Am J Pathol. 2005. 166(4):1229-38.

Relationship between REL amplification, REL function, and clinical and biologic features in diffuse large B-cell lymphomas.

Houldsworth J, Olshen AB, Cattoretti G, Donnelly GB, Teruya-Feldstein J, Qin J, Palanisamy N, Shen Y, Dyomina K, Petlakh M, Pan Q, Zelenetz AD, Dalla-Favera R, Chaganti RS.

Blood. 2004. 103(5):1862-8.

Molecular cytogenetic analysis of genomic instability at the 1q12-22 chromosomal site in B-cell non-Hodgkin lymphoma.

Itoyama T, Nanjungud G, Chen W, Dyomin VG, Teruya-Feldstein J, Jhanwar SC, Zelenetz AD, Chaganti RS.

Genes Chromosomes Cancer. 2002. 35(4):318-28.

Spectral karyotyping identifies new rearrangements, translocations, and clinical associations in diffuse large B-cell lymphoma.

Nanjangud G, Rao PH, Hegde A, Teruya-Feldstein J, Donnelly G, Qin J, Jhanwar SC, Zelenetz AD, Chaganti RS.

Blood. 2002. 99(7):2554-61.

Similar patterns of genomic alterations characterize primary mediastinal large-B-cell lymphoma and diffuse large-B-cell lymphoma.

Palanisamy N, Abou-Elella AA, Chaganti SR, Houldsworth J, Offit K, Louie DC, Terayu-Feldstein J, Cigudosa JC, Rao PH, Sanger WG, Weisenburger DD, Chaganti RS.

Genes Chromosomes Cancer. 2002. 33(2):114-22.

Deregulation of FCGR2B expression by 1q21 rearrangements in follicular lymphomas.

Chen W, Palanisamy N, Schmidt H, Teruya-Feldstein J, Jhanwar SC, Zelenetz AD, Houldsworth J, Chaganti RS.

Oncogene. 2001. 20(52):7686-93.

Splicing factor SRP20 is a novel partner of BCL6 in a t(3;6)(q27;p21) translocation in transformed follicular lymphoma.

Chen W, Itoyama T, Chaganti RS.

Genes Chromosomes Cancer. 2001. 32(3):281-4.

Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas.

Pasqualucci L, Neumeister P, Goossens T, Nanjangud G, Chaganti RS, Küppers R, Dalla-Favera R.

Nature. 2001. 412(6844):341-6.

Recurring chromosomal abnormalities in non-Hodgkin’s lymphoma: biologic and clinical significance.

Chaganti RS, Nanjangud G, Schmidt H, Teruya-Feldstein J.

Semin Hematol. 2000. 37(4):396-411.

Chromosomal amplification is associated with cisplatin resistance of human male germ cell tumors.

Rao PH, Houldsworth J, Palanisamy N, Murty VV, Reuter VE, Motzer RJ, Bosl GJ, Chaganti RS.

Cancer Res. 1998. 58(19):4260-3.

Deregulation of BCL6 in non-Hodgkin lymphoma by insertion of IGH sequences in complex translocations involving band 3q27.

Chaganti SR, Rao PH, Chen W, Dyomin V, Jhanwar SC, Parsa NZ, Dalla-Favera R, Chaganti RS.

Genes Chromosomes Cancer. 1998. 23(4):328-36.

The t(2;3)(q21;q27) translocation in non-Hodgkin’s lymphoma displays BCL6 mutations in the 5′ regulatory region and chromosomal breakpoints distant from the gene.

Chen W, Butler M, Rao PH, Chaganti SR, Louie DC, Dalla-Favera R, Chaganti RS.

Oncogene. 1998. 17(13):1717-22.

Chromosomal and gene amplification in diffuse large B-cell lymphoma.

Rao PH, Houldsworth J, Dyomina K, Parsa NZ, Cigudosa JC, Louie DC, Popplewell L, Offit K, Jhanwar SC, Chaganti RS.

Blood. 1998. 92(1):234-40.

REL proto-oncogene is frequently amplified in extranodal diffuse large cell lymphoma.

Houldsworth J, Mathew S, Rao PH, Dyomina K, Louie DC, Parsa N, Offit K, Chaganti RS.

Blood. 1996. 87(1):25-9.

Comparative genomic hybridization: an overview.

Houldsworth J, Chaganti RS.

Am J Pathol. 1994. 145(6):1253-60.

Gene amplification in non-Hodgkin’s lymphoma.

Ben-Yehuda D, Houldsworth J, Parsa NZ, Chaganti RS.

Br J Haematol. 1994. 86(4):792-7.

Allelic deletions in the long arm of chromosome 12 identify sites of candidate tumor suppressor genes in male germ cell tumors.

Murty VV, Houldsworth J, Baldwin S, Reuter V, Hunziker W, Besmer P, Bosl G, Chaganti RS.

Proc Natl Acad Sci U S A. 1992. 89(22):11006-10.