CGI Patents

CGI’s research program has produced a portfolio of several patents including the design of DNA-FISH probes.

U.S. Patent #7,585,964 (assigned September 2009)

Methods of analyzing chromosomal translocations using Fluorescent in situ Hybridization (FISH)
 
This invention describes probes and methods of using probes to detect chromosomal rearrangements to provide greater selectivity and sensitivity. The probe sets utilized in the detection methods are designed to hybridize to chromosomes at regions outside known breakpoints, instead of spanning the breakpoint as with conventional FISH methods, and, in some instances, are further designed to bind to regions located outside the genes involved in the rearrangement. Probe sets for four translocations have been designed by CGI:

(11;14)(q13; q32) (BCL1; IGH)

t(14;18)(q32; q21) (IGH; BCL2)

t(8;14)(q24; q32) (MYC; IGH)

t(9;22)(q34; q11) (BCR; ABL)

U.S. Patent (approved May 2009, # pending)

Panel for the Detection and Differentiation of Renal Cortical Neoplasms

This invention provides a novel, highly sensitive and specific probe panel which detects the type of kidney cancer present in a biopsy sample. The invention permits diagnosis of the predominant subtypes of renal cortical neoplasms based on the presence/absence of genomic abnormalities in a biopsy specimen as detected by FISH.